IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 14، Issue: 3
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-14-3_008
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. However, IL-17 is reported to be resistant to glucocorticoids in various disorders. Here, we evaluated the plasma level of IL-17 among newly diagnosed and under-treatment SLE patients to understand the effect of glucocorticoids on Th17 response. Methods: A total of 40 female SLE patients and 20 age- and sex- matched normal subjects were enrolled. IL-17 plasma level was evaluated using ELISA cytokine assay and analyzed with previously obtained IL-10, IFN-γ, and GILZ levels. Results: Our findings revealed that IL-17 was overexpressed among under-treatment SLE patients. There was a significant correlation between IL-17 and IFN-γ and significant reverse correlations between IL-17, IL-10, and GILZ levels. IL-17 was not significantly correlated with the disease activity. Conclusion: According to the role of IL-17 in tissue injury and the fact that glucocorticoids are not successful in preventing organ damages in SLE, the overexpressed IL-17 in response to therapies could be introduced as an underlying reason.
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Authors
Saeed Mohammadi
Stem Cell Research Center, Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran|Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Sima Sedighi
Department of Rheumatology, Golestan Rheumatology Research Center, Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran
Ali Memarian
Department of Medical Immunology, Golestan Research Center of Gastroenterology and Hepatology, Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran
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