The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 12، Issue: 3
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-12-3_003
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Background &Objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. Methods: The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014. Immunohistochemistry was applied to detect ER, PR, and Her-2. Results: The current study findings indicated a significant correlation of 90% between CNB and SE specimens for ER expression. The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively. Discussion: CNB can be performed confidently to determine ER and Her-2. For PR, results obtained from CNB should be considered.
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Authors
Fereshteh Ensani
Dept. of Pathology, Cancer Institute Hospital, Tehran University of Medical Sciences, Tehran, Iran
Ramesh Omranipour
Surgical Oncology Center Institute Hospital, Tehran University of Medical Science, Tehran, Iran
Isa Jahanzad
Dept. of Immunohistochemistry, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
Azadeh Jafari
Dept. of Pathology, Cancer Institute Hospital, Tehran University of Medical Sciences, Tehran, Iran
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