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BK Viremia among Iranian Renal Transplant Candidates

عنوان مقاله: BK Viremia among Iranian Renal Transplant Candidates
شناسه ملی مقاله: JR_IJP-11-3_003
منتشر شده در شماره 3 دوره 11 فصل در سال 1395
مشخصات نویسندگان مقاله:

Manizheh Jozpanahi - Zanjan University of Medical Sciences, Zanjan, Iran
Amitis Ramezani - Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
Shahrzad Ossareh - Hasheminejad Kidney Center, Iran University of Medical Science, Tehran, Iran
Mohammad Banifazl - Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran

خلاصه مقاله:
Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and potentially renal allograft rejection, the detection of BKV in renal transplant candidates is very important. The aim of this study was to evaluate the frequency of BK viremia in end stage renal disease cases who were candidates for renal transplantation. Methods: In this cross-sectional study, 50 cases with end stage renal disease who were candidates for renal transplantation were recruited from the main dialysis unit in Tehran, Iran. Presence of BK viremia was determined in plasma samples of cases using real time PCR. Results: A total of 50 renal transplant candidates with mean age 37.8±13 yr were enrolled in the study. Fifty two percent of subjects were male. Forty six (92%) of them were under HD and 4 (8%) were on PD. BK virus was not detected in any plasma samples of renal transplant candidates. Conclusion: This study showed absence of BK viremia in our renal transplant candidates. However, due to the important role of BKV in BKVAN and renal graft failure and rejection, further studies involving larger number of cases are required to elucidate the rate of the BKV in renal transplant candidates.   How to cite this article: Jozpanahi M, Ramezani A, Ossareh S, Banifazl M, Bavand A, Mamishi S, et al. BK Viremia among Iranian Renal Transplant Candidates. Iran J Pathol. 2016; 11(3):210-5.

کلمات کلیدی:
BK virus (BKV), Prevalence, Renal transplant candidates

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