Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_AJP-9-5_003

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Objective: Inflammation along with oxidative stress plays an important role in the development, progression, instability and rupture of coronary atherosclerotic plaques. Several studies introduced curcumin (diferuloylmethane) as a wonderful chemical in Curcuma longa (turmeric) with appropriate anti-inflammatory and antioxidant effects. The effect of curcumin on inflammatory biomarkers was assessed in several clinical trials. This study was designed to evaluate the effect of curcumin on three pro-inflammatory biomarkers in patients with unstable angina. Materials and Methods: Forty patients with unstable angina who met the inclusion criteria, participated in this double-blind randomized clinical trial. Patients were randomly divided into two groups. The patients in the treatment group received nanocurcumin 80 mg per day for 5 days and the control group received placebo 80 mg per day for five days. Blood samples were obtained before the administration, and also 1, 2 and 4 days after taking the treatment. Serum concentrations of Myeloperoxidase (MPO), matrix metalloproteinase-9 (MMP-9) and interleukin 18 (IL-18) biomarkers were measured by ELISA. Results: There was no significant difference in concentration of these biomarkers before the administration and 1, 2 and 4 days after the start of the trial, between the two groups; however, the concentration of IL-18 on the first day significantly varied between the groups. Conclusion: Based on the findings of this study, administration of nanocurcumin capsules at the dose of 80 mg per day for 5 days, did not significantly decrease inflammatory biomarkers in patients with unstable angina.

Authors

Amir hooshang Mohammad pour

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.|Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.

Mostafa Dastani

Department of Cardiology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Roshanak Salari

Department of Clinical Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Sohrab Radbin

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.

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  • Aggarwal BB, Harikumar KB. 2009. Potential therapeutic effects of curcumin, ...
  • Aggarwal BB, Sundaram C, Malani N, Ichikawa H. 2007. Curcumin: ...
  • Alique M, Luna C, Carracedo J, Ramírez R. 2015. LDL ...
  • Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, ...
  • Apple FS, Wu AH, Mair J, Ravkilde J, Panteghini M, ...
  • Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, ...
  • Basnet P, Skalko-Basnet N. 2011. Curcumin: an anti-inflammatory molecule from ...
  • Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M, ...
  • Čejková S, Králová-Lesná I, Poledne R. 2016. Monocyte adhesion to ...
  • Foncea R, Carvajal C, Almarza C, Leighton F. 2000. Endothelial ...
  • Gupta SC, Patchva S, Aggarwal BB. 2013. Therapeutic roles of ...
  • Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. ...
  • Henrotin Y, Gharbi M, Dierckxsens Y, Priem F, Marty M, ...
  • Hiller O, Lichte A, Oberpichler A, Kocourek A, Tschesche H. ...
  • Hulthe J, McPheat W, Samnegård A, Tornvall P, Hamsten A, ...
  • Libby P. 2000. Changing concepts of atherogenesis. J Intern Med, ...
  • Libby P, Ridker PM, Maseri A. 2002. Inflammation and atherosclerosis. ...
  • Lin SS, Lai KC, Hsu SC, Yang JS, Kuo CL, ...
  • Lu H, Ouyang W, Huang C. 2006. Inflammation, a key ...
  • Lucas SM, Rothwell NJ, Gibson RM. 2006. The role of ...
  • Mallat Z, Corbaz A, Scoazec A, Besnard S, Leseche G, ...
  • Priyadarsini KI. 2014. The chemistry of curcumin: from extraction to ...
  • Rosso R, Roth A, Herz I, Miller H, Keren G, ...
  • Saja K, Babu MS, Karunagaran D, Sudhakaran PR. 2007. Anti-inflammatory ...
  • Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, ...
  • Sokolove J, Lepus CM. 2013. Role of inflammation in the ...
  • Sprague AH, Khalil RA. 2009. Inflammatory cytokines in vascular dysfunction ...
  • Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, ...
  • Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, ...
  • ZakynthinosE, Pappa N. 2009. Inflammatory biomarkers in coronary artery disease. ...
  • Zhou H, Beevers CS, Huang S. 2011. The targets of ...
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