The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
View: 426

This Paper With 11 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_AJP-9-5_006

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Objective: Effects of Commiphora mukul and Commiphora myrrha ethanolic extracts and Terminalia chebula hydro-ethanolic extract combination were evaluated in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Male Wistar rats (n=48) were randomly assigned into: control; diabetic; diabetic+metformin (300 mg/kg); diabetic+dose 1 of herbal combination (438 mg/kg of C. mukul+214 mg/kg of C. myrrha+857 mg/kg of T. chebula); diabetic+dose 2 (642 mg/kg of C. mukul+214 mg/kg of C. myrrha+642 mg/kg of T. chebula); and diabetic+dose 3 (857 mg/kg of C. mukul+438 mg/kg of C. myrrha+1714 mg/kg t of T. chebula). All treatments were given orally by gavage. Diabetes was induced by STZ (60 mg/kg, i.p.). At the end of study (day 28), blood glucose, insulin and lipid profile; as well as hepatic malondialdehyde (MDA) and thiol content, and superoxide dismutase (SOD) and catalase (CAT) activities were determined. Results: In diabetic rats, plasma glucose, triglycerides (TG), total cholesterol (TC), and LDL-C, as well as hepatic MDA levels were elevated but plasma HDL-C and insulin, and hepatic thiol content and SOD and CAT activities were reduced compared to control (p<0.01-p<0.001). In diabetic+dose 3, plasma TC, TG, and LDL-C and hepatic MDA level decreased (p<0.001), while plasma HDL-C and insulin, and hepatic thiol content, and SOD and CAT activities increased compared to diabetic (p<0.01-p<0.001). Treatment with dose 1 and 2 improved such abnormalities in diabetic rats except for insulin level (p<0.05-p<0.001). The herbal combination effects were comparable to those of metformin. Metformin did not significantly change serum insulin and HDL-C levels, and hepatic SOD activity; however, serum levels of TC, TG, and LDL-C, as well as hepatic MDA levels, thiol content and CAT activity were improved compared to diabetic (p<0.05-p<0.001). Conclusion: These results indicate that this herbal combination acts as an anti-diabetic, antioxidant and hypolipidemic agent and it may be suggested as a beneficial remedy for diabetic patients.

Authors

Reyhaneh Sotoudeh

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mousa-al-reza Hajzadeh

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Neur

Zahra Gholamnezhad

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Azita Aghaee

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Aebi H. 1984. Catalase in vitro. Methods Enzymol, 105:121-126. ...
  • Ahmadi-Naji R, Heidarian E, Ghatreh-Samani K. 2017. Evaluation of the ...
  • Bellamkonda R, Rasineni K, Singareddy SR, Kasetti RB, Pasurla R, ...
  • Bhat M, Zinjarde SS, Bhargava SY, Kumar AR, Joshi BN. ...
  • Cheng H-Y, Lin T-C, Yu K-H, Yang C-M, Lin C-C. ...
  • Cho N, Shaw J, Karuranga S, Huang Y, da Rocha ...
  • Choi M-K, Kim H-G, Han J-M, Lee J-S, Lee JS, ...
  • El‐Ashmawy IM, Ashry KM, El‐Nahas AF, Salama OM. 2006. Protection ...
  • El Ashry E, Rashed N, Salama O, Saleh A. 2003. ...
  • Francis JA, Raja SN, Nair MG. 2004. Bioactive Terpenoids and ...
  • Gao H, Huang Y-N, Xu P-Y, Kawabata J. 2007. Inhibitory ...
  • Habeeb AF. 1972. Reaction of protein sulfhydryl groups with Ellman ...
  • Helal EG, Mahmoud A, El-Badawy EE, Kahwash AA. 2005. Effect ...
  • Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, ...
  • Ighodaro O, A Adeosun. 2018. Vascular Complications in Diabetes Mellitus. ...
  • Jandeleit-Dahm K, Cooper ME. 2002. Hypertension and diabetes. Curr Opin ...
  • Kannan P, Ramadevi S, Hopper W. 2009. Antibacterial activity of ...
  • Kaveh M, Eidi A, Nemati A and Boskabady MH. 2017. ...
  • Kim J-h, Hong C-O, Koo Y-c, Kim S-J, Lee K-W. ...
  • King GL, MR Loeken. 2004. Hyperglycemia-induced oxidative stress in diabetic ...
  • Kumar GP S, Arulselvan P, Kumar DS, Subramanian SP. 2006. ...
  • Lee H-S, Jung S-H, Yun B-S, Lee K-W. 2007. Isolation ...
  • Lee H-S, Won N. H, Kim K. H, Lee H, ...
  • Madesh M, Balasubramanian KA. 1997. A microtiter plate assay for ...
  • Moussa S. 2008. Oxidative stress in diabetes mellitus. Romanian J ...
  • Naik G, Priyadarsini K, Naik D, Gangabhagirathi R, Mohan H. ...
  • Nasri H. 2013. Toxicity and safety of medicinal plants. J ...
  • Niethammer P, Grabher C, Look AT, Mitchison TJ. 2009. Hydrogen ...
  • Pfundstein B, El Desouky SK, Hull WE, Haubner R, Erben ...
  • Pinhas-Hamiel O, Zeitler P. 2007. Acute and chronic complications of ...
  • Pushparaj P, Tan C, Tan B. 2000. Effects of Averrhoa ...
  • Racine P, Auffray B. 2005. Quenching of singlet molecular oxygen ...
  • Ramesh B, Karuna R, Reddy SS, Sudhakara G, Saralakumari D. ...
  • Ramesh B, Karuna R, Sreenivasa RS, Haritha K, Sai MD, ...
  • Ramesh B, Saralakumari D. 2012. Antihyperglycemic, hypolipidemic and antioxidant activities ...
  • Sasidharan I, Sundaresan A, Nisha V, Kirishna MS, Raghu K, ...
  • Shalaby MA, Hammouda A-E.  2014. Analgesic, anti-inflammatory and anti-hyperlipidemic activities ...
  • Sharma B, Salunke R, Srivastava S, Majumder C, Roy P. ...
  • Shen T, Li G-H, Wang X-N and Lou H-X. 2012. ...
  • Sheng Z, Zhao J, Muhammad I, Zhang Y. 2018. Optimization ...
  • Shokoohi R, Kianbakht S, Faramarzi M, Rahmanian M, Nabati F, ...
  • Shukla R, Sharma SB, Puri D, Prabhu K, and Murthy ...
  • Singh RB, Niaz MA, Ghosh S. 1994. Hypolipidemic and antioxidant ...
  • Su S, Duan J, Chen T, Huang X, Shang E, ...
  • Swanston-Flatt S, Day C, Bailey C, Flatt P. 1990. Traditional ...
  • Turban S, Stretton C, Drouin O, Green CJ, Watson ML, ...
  • Ullah A, Khan A, Khan I. 2015. Diabetes mellitus and ...
  • Urizar NL, Liverman AB, D nette TD, Silva FV, Ordentlich ...
  • Wei L, Ren F, Zhang X, Wen T, Shi H, ...
  • Zhou J, Massey S, Li L. 2018. (Metformin: An Old ...
  • نمایش کامل مراجع