In vitro protoscolicidal effects of various concentrations of Ziziphora tenuior L. extract at different exposure times
Publish place: Avicenna Journal of Phytomedicine، Vol: 6، Issue: 4
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJP-6-4_002
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Objective: Hydatidosis is one of the most important zoonotic diseases and surgery is still the main treatment for this problem. One of the side effects of hydatid cyst surgery is recurrence, thus, searching and assessment of some new agents such as medicinal plant extracts are very important. In the present study, the scolicidal effect of ethanolic extract of Ziziphora tenuior L. (Z. tenuior) was investigated. Materials and Methods: Protoscolices were aseptically collected from sheep livers containing hydatid cyst and used in the experiments. Z. tenuior extract was used at concentration of 3-100 mg/ml for 10-60 min. Viability of protoscolices was determined by 0.1% eosin staining. Results: Based on our results, Z. tenuior extract at concentration of 10 mg/ml killed all protoscolices after 20 min. However, this medicinal plant at concentration of 25 mg/ml destroyed all protoscolices in a shorter exposure time (10 min). Therefore, the scolicidal activity of the extract at 10 and 25 mg/ml concentrations was considerably effective in lower concentrations and shorter exposure times. Conclusion: The findings of this study showed that the ethanolic extract of Z. tenuior produces high scolicidal activity; it may be used as an appropriate and effective scolicidal agent in hydatidosis surgery. This is the first report on the protoscolicidal activity of Z. tenuior.
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Authors
Mojtaba Shahnazi
Department of Parasitology, Qazvin University of Medical Sciences, Qazvin, Iran
Abbas Azadmehr
Department of Immunology, Babol University of Medical Sciences, Babol, Iran
Robabeh Latiffi
Department of Parasitology, Qazvin University of Medical Sciences, Qazvin, Iran
Reza Hajiaghaee
Department of Pharmacognosy & Pharmaceutics Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
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