Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
View: 391

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_AJP-6-1_008

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Objectives: In previous studies the therapeutic effects of Nigella sativa have been demonstrated on asthmatic animals. In the present study, the preventive effect of single dose of alpha-hederin, its active constituent, has been evaluated on lung inflammation and some inflammatory mediators in lungs of ovalbumin sensitized rat in order to elicit its mechanism. Materials and methods: Forty rats were randomly grouped in 4 groups; control (C), sensitized (S), sensitized pretreated groups with thymoquinone (3 mg/kg i.p., S+TQ) and alpha-hederin (0.02 mg/kg i.p., S+AH). Levels of IL-13 mRNA and miRNA-126 in lung tissue and its pathological changes in each group were assessed. Results: Elevated levels of miRNA-126, IL-13 mRNA and pathological changes were observed in the sensitized group compared to the control group (pConclusion: The results suggested that alpha-hederin had preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.

Authors

Maryam Fallahi

Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Rana Keyhanmanesh

Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Amir Mahdi Khamaneh

Department of molecular medicine, School of advanced medical sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Ali Ebrahimi Saadatlou

Department of basic sciences, College of veterinary medicine, Tabriz branch, Islamic Azad University, Tabriz, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Abd El Aziz AE, El Sayed NS, Mahran LG. 2011. ...
  • Alipour MR, Khamaneh AM, Yousefzadeh N, Mohammad-nejad D, Soufi FG. ...
  • Al-JawadFH, Al-Razzuqi RAM, Hashim HM, Ismael AH. 2012. Broncho-relaxant activity ...
  • Angulo M, Lecuona E, Sznajder JI. 2012. Role of MicroRNAs ...
  • Barnes PJ. 2001. Th2 cytokines and asthma: an introduction. Respir ...
  • Boskabady MH, Aslani MR. 2005. Possible relaxant effects of thymoquinone ...
  • Boskabady MH, Mohsenpoor N, Takaloo L. 2010. Antiasthmatic effect of ...
  • Bosnjak B, Stelzmueller B, Erb KJ, Epstein MM. 2011. Treatment ...
  • Collison A, Herbert C, Siegle, J. Mattes, P. S. Foster ...
  • Collison A, Mattes J, Plank M, Foster PS. 2011a. Inhibition ...
  • Gepdiremen A, Mshvildadze V, Süleyman H, Elias R. 2005. Acute ...
  • Greene CM, Gaughan KP. 2013. microRNAs in asthma: potential therapeutic ...
  • Grünig G, Corry DB, Reibman J, Wills-Karp M. 2012. Interleukin ...
  • Hocaoglu AB, Karaman O, Erge DO, Erbil G, Yilmaz O, ...
  • Hosseinzadeh H, Eskandari M, Ziaee T. 2008. Antitussive effect of ...
  • Keyhanmanesh R, Boskabady MH, Khamneh S, Doostar Y. 2010. Effect ...
  • Keyhanmanesh R, Gholamnezhad Z, Boskabady MH. 2014b. The relaxant effect ...
  • Keyhanmanesh R, Pejman L, Omrani H, Mirzamohammadi Z, Shahbazfar AA. ...
  • Kumar M, Ahmad T, Sharma A, Mabalirajan U, Kulshreshtha A, ...
  • Mattes J, Collison A, Plank M, Phipps S, Foster PS. ...
  • May R, Monk P, Cohen E, Manuel D, Dempsey F, ...
  • Oglesby IK, Mc Elvaney NG, Greene CM. 2010. MicroRNAs in ...
  • Rad MK, Neamati A, Boskabady MH, Mahdavi-Shahri N, Mahmoudabady M. ...
  • Rooney S, Ryan M. 2005. Modes of action of alpha-hederin ...
  • Saadat S, Mohammadi M, Fallahi M, keyhanmanesh R, Aslani MR. ...
  • Tsitsiou E, Williams AE, Moschos SA, Patel K, Rossios C, ...
  • Wolf A, Gosens R , Meurs H, Häberlein H. 2011. ...
  • Yang M, Mattes J. 2008. Discovery, biology and therapeutic potential ...
  • نمایش کامل مراجع