The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
View: 391

This Paper With 13 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_AJP-6-1_011

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed. Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pConclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).

Authors

Fatemeh Norouzi

Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Azam Abareshi

Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Akbar Anaeigoudari

Department of Physiology, School of Medicine, Jiroft University of medical Sciences, Jiroft, Iran

Mohammad Naser Shafei

Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, ...
  • Ali BH, Blunden G. 2003. Pharmacological and toxicological properties of ...
  • Azizi-Malekabadi H, Hosseini M, Pourganji M, Zabihi H, Saeedjalali M, ...
  • Azizi-Malekabadi H, Pourganji  M, Zabihi H, Saeedjalali M, Hosseini M. ...
  • Beheshti F, Hosseini M, Shafei MN, Soukhtanloo M, Ghasemi S, ...
  • Burton MD, Sparkman NL, Johnson RW. 2011. Inhibition of interleukin-6 ...
  • Chourbaji S, Urani A, Inta I, Sanchis-Segura C, Brandwein C, ...
  • Contreras CM, Rodriguez-Landa Jf, Fau - Gutierrez-Garcia  AG, Gutierrez-Garcia Ag, ...
  • Coppen AJ, Doogan DP. 1988. Serotonin and its place in ...
  • Dantzer  R, O’Connor  JC, Lawson MA, Kelley KW. 2011. Inflammation-associated ...
  • Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham  L, ...
  • Dunn AJ.2000. Cytokine activation of the HPA axis. Ann N ...
  • Dunn AJ. 2006. Effects of cytokines and infections on brain ...
  • Dunn A  J, Wang  J, Ando T. 1999. Effects of ...
  • El Gazzar MA. 2007. Thymoquinone suppressses in vitro production of ...
  • el Tahir  KE, Ashour MM, al-Harbi MM. 1993. The respiratory ...
  • Entok  E, Ustuner MC, Ozbayer C, Tekin N, Akyuz F, ...
  • Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, ...
  • Gilhotra N, Dhingra D. 2011. Thymoquinone produced antianxiety-like effects in ...
  • Hajhashemi V, Ghannadi A, Jafarabadi H. 2004. Black cumin seed ...
  • Helal GK. 2010. Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction ...
  • Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, ...
  • Hosseini M, Zakeri S, Khoshdast S, Yousefian FT, Rastegar M, ...
  • Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. ...
  • Houghton PJ, Zarka R, de las Heras B, Hoult JR. ...
  • Howren MB, Lamkin DM, Suls J. 2009. Associations of depression ...
  • Hritcu L, Gorgan LD. 2014. Intranigral lipopolysaccharide induced anxiety and ...
  • Janssen DG, Caniato RN, Verster JC, Baune BT. 2010. A ...
  • Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, ...
  • Kang A, Hao H, Zheng X, Liang Y, Xie Y, ...
  • Lawson MA, Parrott JM, McCusker RH, Dantzer R, Kelley KW, ...
  • Layé S, Gheusi G, Cremona S, Combe C, Kelley K, ...
  • Leonard BE. 2001. The immune system, depression and the action ...
  • Ma XC, Jiang D, Jiang WH, Wang F, Jia M, ...
  • Maes M, Berk M, Goehler L, Song C, Anderson G, ...
  • Maes M, Kubera M, Obuchowiczwa E, Goehler L, Brzeszcz J. ...
  • Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, ...
  • Mahgoub AA. 2003. Thymoquinone protects against experimental colitis in rats. ...
  • Maier SF, Watkins LR. 1995. Intracerebroventricular interleukin-1 receptor antagonist blocks ...
  • Miller AH. 2010. Depression and immunity: a role for T ...
  • Mohamed A, Afridi DM, Garani O, Tucci M. 2005. Thymoquinone ...
  • Neamati A, Chaman F, Hosseini M, Boskabady MH. 2014. The ...
  • Perveen T, Haider S, Kanwal S, Haleem DJ. 2009. Repeated ...
  • Petit-Demouliere B, Chenu F Fau - Bourin M, Bourin M.2005. ...
  • Piser TM. 2010. Linking the cytokine and neurocircuitry hypotheses of ...
  • Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini SM, ...
  • Pourganji M, Hosseini M, Soukhtanloo M, Zabihi H, Hadjzadeh MA. ...
  • Quan N, Sundar SK, Weiss JM. 1994. Induction of interleukin-1 ...
  • Raison CL, Capuron L, Miller AH. 2006. Cytokines sing the ...
  • Trends Immunol, 27: 24-31. ...
  • Sharp LK, Lipsky MS. 2002. Screening for depression across the ...
  • Swamy SM, Tan BK. 2000. Cytotoxic and immunopotentiating effects of ...
  • Swiergiel AH, Dunn AJ. 2007. Effects of interleukin-1β and lipopolysaccharide ...
  • Szentirmai É, Krueger JM. 2014. Sickness behaviour after lipopolysaccharide treatment ...
  • Takao T, Culp SG, De Souza EB. 1993. Reciprocal modulation ...
  • Taksande BG, Chopde CT, Umekar MJ, Kotagale NR. 2015. Agmatine ...
  • Tekeoglu I, Dogan A, EdizL, Budancamanak M, Demirel A. 2007. ...
  • Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, ...
  • Vafaee F, Hosseini M, Hassanzadeh Z, Edalatmanesh MA, Sadeghnia HR, ...
  • Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, ...
  • Wang Y, Gao H, Zhang W, Fang L. 2015. Thymoquinone ...
  • Worthen DR, Ghosheh OA, Crooks PA. 1998. The in vitro ...
  • نمایش کامل مراجع