The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits
Publish place: Avicenna Journal of Phytomedicine، Vol: 4، Issue: 3
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
View: 289
This Paper With 7 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_AJP-4-3_001
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Objective: This study was designed to investigate the effect of hydroalcoholic extract and essential oil of Heracleum persicum (Apiaceae) on lipid profile of male hyperlipidemic rabbits. Materials and Methods: Thirty rabbits were randomly divided into six groups of five each. One group received normal diet and the other groups fed with a high cholesterol (2% W/W) diet for 7 weeks. Vehicle, hydroalcoholic extract (500 and 1000 mg/kg), essential oil (200 ml/kg), and lovastatin (5 mg/kg) were administered orally to animals and their effects on lipid profile were evaluated. Results: Essential oil of H. perscum significantly (p<0.05) lowered serum triglyceride level and increased HDL-cholesterol concentration. Moreover, hydroalcoholic extract (1000 mg/kg), essential oil (200 ml/kg), and lovastatin significantly (p<0.01) reduced serum concentration of total cholesterol and LDL-cholesterol. Conclusion: These findings suggest that essential oil of the plant fruits may have some benefits in reducing cardiovascular risk factors.
Keywords:
Authors
Valiollah Hajhashemi
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
Gholamreza Dashti
Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
Salabali Saberi
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
Parvin Malekjamshidi
Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :