Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats
Publish place: Avicenna Journal of Phytomedicine، Vol: 2، Issue: 2
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJP-2-2_003
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS).
Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).
Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST.
Conclusion: Our study demonstrated the potential antidepressant activity of MS.
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Authors
Ghulam Moinuddin
Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-۵۶۰۰۲۷. India
Kshama Devi
Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-۵۶۰۰۲۷. India
Deepak Kumar Khajuria
Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-۵۶۰۰۲۷. India