Mohammad Reza Poor Heravi - Department of Chemistry, Payame Noor University, Abhar, Iran
Naheed Morsalie - aDepartment of Chemistry, Payame Noor University, PO Box ۱۹۳۹۵-۳۶۹۷, Tehran, IRAN

Highly substituted 1,4-dihydropyrano[2,3-c]pyrazole derivatives were synthesized by four-component reaction of aromatic aldehydes, malononitrile, ethyl acetoacetate and various phenylhydrazine, using nickel ferrite as a recyclable nanocatalyst by a grinding method under solvent-free and thermal conditions. The reaction has the advantages of good yields, less pollution, ease of separation of the desired products, and of being environment friendly. A possible mechanism for this reaction was proposed. Highly substituted 1,4-dihydropyrano[2,3-c]pyrazole derivatives were synthesized by four-component reaction of aromatic aldehydes, malononitrile, ethyl acetoacetate and various phenylhydrazine, using nickel ferrite as a recyclable nanocatalyst by a grinding method under solvent-free and thermal conditions. The reaction has the advantages of good yields, less pollution, ease of separation of the desired products, and of being environment friendly. A possible mechanism for this reaction was proposed.

1, 4-Dihydropyrano[2, 3-c]pyrazoles, one-pot synthesis, four component reaction, nickel-ferrite nanoparticles nanocatalyst