Vivekanand Jadhav - shri muktanand college, gangapur, dist.-aurangabad
Mohasim M. Patel - Department of Chemistry, Shri Muktanand College, Gangapur, Dist.-Aurangabad,Pin-۴۳۱ ۱۰۹, Maharashtra

Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oC. Current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.In conclusion, we have explored nicely the synthetic utility of TBAOH as a commercially available, efficient, mild, straightforward, simple, environmentally and economically friendly organo-basic catalyst for the synthesis of diverse Pyrano[2,3-d]pyrimidinone derivtives. Thus we have developed a novel, simple and highly efficient one potmulticomponent reaction protocol for the synthesis of Pyrano[2,3-d]pyrimidinone derivtives in ethanol:water solvent system.

Barbituric acid, malononitrile, aromatic aldehyde, tetra-N-butyl ammonium hydroxide