Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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JR_ICC-5-2_009

تاریخ نمایه سازی: 2 مهر 1398

Abstract:

Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with N-methyl aniline affording thiazine derivative (7). In addition, it was reacted with cyanoacetamide producing mercaptopyrimidine derivative (9). Finally, compound (1) was refluxed with phenylhydrazine, urea, guanidinum carbonate and anthranilic acid in the presence of dry acetone affording triazole derivative (11), N-substituted pyrimidine (15), compound (18) and thiopyrimidine derivative (19) respectively. The structures of the new compounds were confirmed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as anticancer.

Authors

Amira A. Ghoneim

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, EG‐۴۴۵۱۹, Egypt

Mohamed G. Assy

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egyp

Enaiat K. Mohamed

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Islam Ragab

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egyp

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