Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives
Publish place: Iranian Chemical Communication، Vol: 5، Issue: 2
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ICC-5-2_009
تاریخ نمایه سازی: 2 مهر 1398
Abstract:
Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with N-methyl aniline affording thiazine derivative (7). In addition, it was reacted with cyanoacetamide producing mercaptopyrimidine derivative (9). Finally, compound (1) was refluxed with phenylhydrazine, urea, guanidinum carbonate and anthranilic acid in the presence of dry acetone affording triazole derivative (11), N-substituted pyrimidine (15), compound (18) and thiopyrimidine derivative (19) respectively. The structures of the new compounds were confirmed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as anticancer.
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Authors
Amira A. Ghoneim
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, EG‐۴۴۵۱۹, Egypt
Mohamed G. Assy
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egyp
Enaiat K. Mohamed
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
Islam Ragab
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egyp
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