Protective and Risk Factors in Multiple Sclerosis

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJMR-6-2_005

تاریخ نمایه سازی: 2 مهر 1398

Abstract:

Several factors are involved in susceptibility to multiple sclerosis (MS)and alterations in disease activity. A full understanding regarding the mechanism which causes the disease is still lacking. Several factors have been considered to be associated, positively or negatively, with the onset, course, progression, and relapse rates of MS. However, the level of consensus on each factor is different. These factors are either genetic (including polymorphisms in human leukocyte antigen, microRNAs genes, etc) or environmental (such as serum levels of circulating vitamin D, helicobacter pylori, Epstein-Barr virus, human cytomegalovirus, human herpes virus type 6, human endogenous retrovirus infections, and latitude). Vitamin D sufficiency is a major protective factor on which there is a decisive consensus and has known interactions with many factors affecting MS onset/severity. Vitamin D therapy is speculated to exert beneficial effects on patients, the efficacy of which, along with the etiology of MS, is reviewed in this article.

Authors

Hosein Nouri

Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Homayoun Tabesh

Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran

Masih Saboori

Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran|Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran

Karim Sohrabi

Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran