Querectin: improve myelin repair and reduce glial activation of the optic pathway in lyolecithin-induced focal demyelination model

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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CSUMSMED05_050

تاریخ نمایه سازی: 7 مهر 1398

Abstract:

Multiple sclerosis (MS) is one of the most inflammatory disease in worldwide. Demyelination and disturbance of action potential conductance are regarded as main signs of MS disease. Quercetin is regarded as one of the most abundantnatural flavonoids which is present in several vegetables and fruits possesses a wide range of pharmacological functions, including anti-tumor effects, anti-oxidant and antiviral activities. The present study attempts to evaluate the effects of quercetin on myelin repair and glial activation in lysolecithin (LPC)-induced demyelination model. Local demyelination was induced by administration of LPC (1%, 2μL) into the rat optic chiasm. Animals have received oral administration quercetin at doses 25 or 50mg/kg for 7 and 14 days post lesion. Visual evoked potential (VEPs) recordings were used to assess the functional property of the optic pathway on days 0, 7, 14 post lesions. Immunostaining against Iba 1 (microglia marker) and GFAP( astrocytes marker) were carried out for evaluation of myelination and astrocytes activation. Electrophysiological data indicated that LPC injection increased the latency of VEPs waves and quercetin effectively reduced the delay of visual signals. The level of glial activation was alleviated in animals under treatment of quercetin compared to vehicle group. Furthermore, quercetin treatment decreased the extent of demyelination areas and increased the remyelination process following LPC injection. Overall, our findings indicate that quercetin could remarkably improve the functional recovery of the optic pathway by its protective effects on myelin sheath and attenuation of glial activation.

Authors

Saeideh Baradaran

Research Committee, Babol University of Medical Sciences, Babol, Iran

Reza Naeimi

Research Committee, Babol University of Medical Sciences, Babol, Iran

Manouchehr Ashrafpour

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran . Department of Physio

Ali Akbar Moghadamnia

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.Department of Pharmacology, Faculty of Medical Sciences, Babol University of Medical Sciences, Babol,Iran