Surfactant Administration via Thin Catheter during Spontaneous Breathing: Randomized Controlled Trial in Alzahra hospital

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
View: 310

This Paper With 5 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IRJN-4-2_002

تاریخ نمایه سازی: 9 مهر 1398

Abstract:

Introduction Respiratory distress syndrome (RDS) is a current cause of morbidity in premature infants resulted from surfactant deficiency. The primary aim of this randomized study was to describe the feasibility of early administration of surfactant via a thin catheter during spontaneous breathing (TEC) and compare its outcomes with the InSurE (Intubate, Surfactant, Extubate) procedure Materials and Methods Premature infants with RDS, who were ≤ 32 weeks old and stabilized with nasal continuous positive airway pressure (nCPAP), were randomized to receive surfactant either by the TEC or InSurE technique. Tracheal instillation of 200 mg/kg Curosorf via 5-F catheter during spontaneous breathing under nCPAP was performed in the intervention group (n=38). In the InSurE group (n=40), infants were intubated, received positive pressure ventilation for 30 seconds after surfactant instillation, and placed on nCPAP immediately Results Necrotizing enterocolitis rate was significantly lower in TEC group, than InSurE group, [p<0.02, RR=0.49, CI=%95(0.39_0.62)]. But rate of other morbidities did not significant difference between two groups. Although Mechanical ventilation duration did not significant different between two groups (p=0.2), but Total CPAP duration was shorter in TEC group, significantly [P<0.01, RR=8.2, CI=%95 (-37.9_-4.8)]. Need for O2 supplement and mean of total hospital duration was also lower in TEC group, but was not significant, statistically Conclusion The TEC technique is feasible for the treatment of respiratory distress syndrome in infants with very low birth weight and decreases total nCPAP duration, significantly. But Judgment of substitution TEC instead of InSurE as a routine technique need to more studies.

Authors

Kayvan Mirnia

Neonatologist, Pediatrics Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Heidarzadeh

Assistant Prof. of Neonatology, Dept. of Pediatrics, Tabriz University of Medical Sciences, Director of Dept. of Neonatal Health, Ministry of Health & Medical Education, Tabriz ,Iran

Mohammad Bagher Hoseini

Associated Prof. of Neonatology, Dept. of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran

Alireza Sadeghnia

Assistant prof. of Neonatology, Isfahan University of Medical Sciences, Isfahan, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Hamvas A MR, Fanaroff AA, Walsh MC. Pathophysiology and Management ...
  • Turunen R NI, Siitonen S, Repo H, Andersson R  Onset ...
  • Prophylactic versus selective use of surfactant in preventing morbidity and ...
  • Donn S, Sinha S. Minimising ventilator induced lung injury in ...
  • Dani C, Bertini G, Pezzati M, Cecchi A, Caviglioli C, ...
  • Afjeh SA SS. The INSURE method in VLBW preterm infant ...
  • Kramer BW IM, Jobe A Intratracheal endotoxin causes systemic inflammation ...
  • Kribs A HC, Kattner E, Vochem M, Kuster H, Moller ...
  • Kribs A, Pillekamp F, Hünseler C, Vierzig A, Roth B. ...
  • Kribs A, Vierzig, A., Hünseler, C., Eifinger, F., Welzing, L., ...
  • Kattwinkel J, Robinson M, Bloom BT, Delmore P, Ferguson JE. ...
  • Kattwinkel J. Textbook of neonatal resuscitation  5th ed: AAP; 2006. ...
  • Society AN. Acute Care at Risk Newobrns (ACoRN) 2010. Available ...
  • Dargaville PA, Aiyappan A, De Paoli AG, Kuschel CA, Kamlin ...
  • Kanmaz G EO, Canpolat E,Mutlu B,Dilmen U. Surfactant Administration via ...
  • نمایش کامل مراجع