Etiologies and Antibiotic Resistance Patterns in Infants With Urinary Tract Infections Hospitalized in Children Medical Center, Rasht, Iran

Introduction Urinary tract infection (UTI) is one of the most common infections in childhood. Appropriate treatment of UTI requires to knowledge about antibiotic resistance patterns of common uropathogens. The aim of this study was to determine demographic, symptoms, signs and antibiotic resistance pattern in admitted infants with clinically diagnosis of UTI in 17 Shahrivar Hospital of Rasht Materials and Methods This retrospective study was performed on 77 patients less than 2 years old from March 2006 to march 2011. They were admitted with clinical diagnosis of UTI and posilive. Urine cultures data (demographic, symptoms, signs and the results of urine analysis and urine cultures) were analyzed by SPSS and Chi-squart Results From 77 patients, 53.2% were female, with mean age of 8.07 ± 6.84 months. The most common symptom was fever(48.1%) vomiting and diarrhea were second and third prevalent symptom. 18.1% had leukocytosis and CRP was positive in 67.3%. Leukocyturia in 58.4% and hematuria in 19.5% of them were seen. The most common agent was E coli (59.7%) followed by Klebsiella and Enterobacter (14.3%) and Coagulase negative Staphylococcus (5.2%). Isolated pathogens were resistance to ampicillin (94.1%), amoxicillin (88.9%), cefalexin (70.5%), co-trimoxazole (66.7%), cefixime (75%). This antibiotic resistance was less for nalidixic acid (37%), ceftriaxone (20%), aminoglycosids (24.6%), nitrofurantoin (22.4%) and ciprofloxacin (14.8%). Conclusion Ecoli was the most frequent pathogen in our study. Resistance to all antibiotics used to treat UTI was common. Due to the low sensitivity of ampicillin, amoxicillin, cefalexin and co-trimoxazole, use of them is not recommended for the treatment of UTI. It seems that the best choices include ceftriaxone, aminoglycosids, nalidixic acid, and nitrofurantoin

Keywords:

Urinary tract infection , Antibiotic resistance , Children , Rasht