Evaluation of antibiotic prescription pattern in Fatimah Zahra heart hospital of Sari, at north of Iran; one year survey

Background: Given the widespread use of antibiotics, antibiotic resistant organisms that cause nosocomial infection is increasing rapidly. To modify the pattern of antibiotic consumption requires accurate information about their current prescription.Material & method: This study aimed to investigate the pattern of antibiotic use in Sari Fatima Zahra hospital from April 2011 to March 2012. This study was a retrospective drug utilization evaluation based on ATC / DDD system.Results: Sari Fatima Zahra hospital had an occupancy index 0/91 with an 8564 Admission. In total 355 patients received antibiotics that 55.25% were male &44.8% female. The most common illnesses were including; pneumonia (45.6%), surgical wound infection (16.3%), endocarditis (15.2%), urinary tract infection (6.8%), sepsis (6.5%) &mediastinitis (9 / 3%), respectively. The antibiotic cost was 15.14% of all drug costs. Antibiotics were administered intravenously in 93.34% of cases. The most commonly used drugs were ceftriaxone (in 65.6%) that the most common indication for its use was pneumonia (59.7%) & endocarditis (16.7%), respectively. The second was vancomycin (54.6%) that the most common causes for its use were pneumonia (29.8%), surgical wound (26.8%) and endocarditis (21.8%), respectively. Clindamycin was prescribed in 35.3% and imipenem in 21.4% of patients. The use of antibiotics using the defined daily dose was calculated 423 for total drugs and 140.32 &111.3 for ceftriaxone & vancomycin, respectively.Conclusion: Despite the relatively good use of antibiotics in our hospital, the use of essential drugs, vancomycin and imipenem was high. This is partly due to type of our patient’s disease (heart surgery) and party due to lack of sufficient knowledge about common objects antibiotic resistance in hospitals. Thus, scientific, accurate and acceptable studies in this context would be helpful.

Keywords:

Antibiotic use , Antibiotic resistance , Antibiotic stewardship