Mohammad Ali Shatalebi - Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Behzad Zolfaghari - Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy andPharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Milad Rashidbeygi - Student Research Committee, Ilam University of medical sciences, Ilam, Iran
Somayeh Morshedi - Student Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University ofMedical Sciences, Isfahan, Iran

Objective: One of the aims of medicine is to heal wounds in a shorter time and with fewer complications. In thestudies on the effect of Scrophularia striata Boiss on the probability of mitigation of infection, reduction of thewound healing period, inflammation and scar remaining from the wound have been shown. Gel maskformulation, enjoying PVA polymer, creates a natural scaffold on wounds, causing the cells to migrate in anorganized fashion towards the wound s bed and proliferate. By introducing the plant s extract in this base, itseffect on reduction of the healing time and mitigation of the scar remaining from the wound becomespredictable.Methods: The total plant was extracted through percolation using ethanol 70%. The plant s standardization wasdone through determination of the total polyphenols percentage using folin-ciocalteu reagent. The extract wasthen concentrated and the amount of the dry extract per each 100 g of the plant s powder was calculated. Next,different formulations with different percentages of PVA, ethanol, isopropyl alcohol, propylene glycol, andglycerin and other substances available in the base were prepared and then evaluated in terms of formation ofmedicinal film, drying time, pH, and other physiochemical parameters. Thereafter, drug diffusion wasinvestigated using Franz cell and drug diffusion kinetics from the base.Results: The amount of the plant s polyphenols was 25.1% and the amount of the plant s dry extract was 12.5%.The optimal formulation is a clear gel that forms a medicinal film after application of wound and following 10minutes of use. It contains 7.5% pva, 15% alcohol, 10% isopropyl alcohol, 0.5% xantam, and 3% glycerin. ThepH of the formulation was 5.65 and had the stability required in physiochemical evaluations and stabilityexperiments. Drug release was done within 35 min as much as 90%, with the drug s release model followingHiguichi model.Conclusion;The optimal gel mask formulation containing 10% the extract of Scrophularia striata Boiss plantindicated a desirable stability in physiochemical evaluation. Considering the synergistic effect of the base andthe extract in shortening the wound healing period and mitigation of remaining scar, clinical studies should beconducted.

Scrophularia striata Boiss, gel mask, wound, film-forming gel