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Mycosis Fungoides Skin Wound Management With Skin Graft Post Ultraviolet Radiation therapy

عنوان مقاله: Mycosis Fungoides Skin Wound Management With Skin Graft Post Ultraviolet Radiation therapy
شناسه ملی مقاله: JR_INTJMI-5-3_008
منتشر شده در شماره ۳ دوره ۵ فصل در سال 1395
مشخصات نویسندگان مقاله:

Shefaa Almashagbeh - department of Dermatology, department at king Hussein Medical Center. Amman –Jordan
Alaa Jmean - Plastic surgery Department, Royal medical services, Amman –Jordan
Hayat Khasawneh - Pathology Department ,Royal medical services, Amman –Jordan
Deifallah Alsharari - Internal medicine Department, Royal medical services, Amman –Jordan

خلاصه مقاله:
Objective : To assess the survival rate of skin graft management in skin lesions of mycosis fungoides patientsafter therapy with ultraviolet radiation.Methods : Between February. 2011 and June 2015, 89 [8- 81 yrs. ] mycosis fungoides patients werefollowed up at dermatology clinic, the initial investigations were skin biopsy and the most common usedtherapy is photo therapy with ultraviolet radiation ( according to stage in the histopathologic reports )Results : Of the 89 patients that we followed , 90% treated with phototherapy (80 patients ), 35% of them (28patients ) of these patients were managed by skin grafts of skin lesions and ulcers , 10% of them ( 3patients )the skin graft didn’t survive without previous therapy with ultraviolet radiation , 90% (25patients ) of them thegrafted areas survived after phototherapy of UVA ,UVB radiation to the potential donor site, the other 65%(52patients ) of the followed pts were managed without skin graft for the ulcerated skin lesions , 38% of themhealed spontaneously , others didn’t healed for a long time and need skin graft.Conclusion: Mycosis fungoides is the most common type of cutaneous T lymphoma, pts who receivedphototherapy to the potential donor site has proven beneficial for skin graft survival , since ultraviolet radiationA,B ,decrease the cytotoxic T lymphocyte activity and decrease inflammatory cells in both graft and donortissues , with decrease in the antigen presenting cells expression, which leads to decrease in the delayed typehyper sensitivity reaction and increase graft uptake.

کلمات کلیدی:
Mycosis fungoides , skin graft , phototherapy

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/937113/