Elham Mobasheri - Gorgan Congenital Malformations Research Center, Department of Anatomical Sciences, Golestan University of Medical Sciences, Gorgan, Iran
Hamed Jafarpour - Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Arash Rezaei - Medical Student, Student Research Committee, Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran
Zanbagh Piraste Far - Resident of Gynecology, Research & Development Center Hospital Sayyed Shirazi, Golestan University of Medical Sciences, Golestan, Iran

Introduction: Rupturing of fetal membranes before week 37 is called preterm premature rupture ofmembranes (PPROMs). The pathogenesis of PPROM is not definite but it seems that many mechanicaland physiological etiologies are involved. As the most important risk factors, having a late history of thesame disease, genital infection, prepartum bleeding and smoking can be named. Premature rupture of themembranes is usually seen in preterm births and it accounts for about 1/3 of them.Methods: This interventional semi experiencing study was done on patients visiting the Sayyad Shirazihospital in Gorgan with a chief complaint of leaking fluid in week 24 up to 34 of pregnancy. Noticeableneonatal complications in this study were birth time Apgar, admission in NICU, birth weight and IUGR.All of the neonates entered the study with a gestational age of fewer than 34 weeks and admitted with adiagnosis of probable sepsis. Neonates with congenital abnormalities, asphyxia, respirational distresssyndrome, meconium aspiration syndrome and birth weight less than 1000 gram exited the study. Datawas analyzed with SPSS16 statistical software and Chi2 test, independent T-test and ANOVA.Findings: Admission length time until labor in the group that did not receive antibiotics was less than theother group and average admission length time between the two groups was statistically meaningful(P=0.00). In the Group that received antibiotics, on order 25, 50 and 75 percent of patients had admissionlength time of 7, 4 and 12 days and these percentages for the other group are 5, 3 and 7 days. Also, therewas not any significance difference between the other two variables, which are the type of labor and feverfrequency, and chorioamnionitis.Conclusion: According to the results, usage of antibiotics lengthens the late stage of labor and it isprobably effective in decreasing the premature neonate complications. Therefore using of antibiotics in premature rupture of amniotic fluid is suggested.

maternal, PPROM, Premature