Comparing effect of oxytocin versus oxytocin-propranolol combination on labor progression

Introduction: Elective induction of labor increase the risk of cesarean section rate. pharmacological methods Including prostaglandins and oxytocin that are used. Another thing that may be helpful in the process of induction (propranolol), which is a type 1 and 2 beta-adrenergic receptor blocker. Stimulation of these receptors inhibits uterine contractions. Due to the inconsistent results from different studies as well as the small number of studies in this field, and the importance of the potential side effects of high doses of oxytocin on the health of the mother and fetus, this study aimed to evaluate the use of propranolol plus oxytocin compared with oxy oxytocin alone on the progress of the delivery.Methods: This study was a controlled double-blind clinical trial, and 50 cases in each group. inclusion and exclusion criteria were considered. In Group oxytocin, oxytocin was started in 2 mIu / ml, and every 15 minutes in the same amount was added to the good contractions (three good contractions in 10 min), respectively, then 8 hours continued. In the propranolol group, before induction, 2 mg propranolol intravenously and slowly at a speed of 1 mg per minute were injected and then with oxytocin induction was established as above. Delivery and patient follow-up data were recorded.Findings: In our study, the effect of propranolol on labor were investigated, propranolol has been able to reduce the duration of latent phase in the case group than the control group. (P =0.000). The mean duration of the active phase and second stage of labor were studied in two groups was not statistically significant, (P =0.703) for the duration of the active phase and (P =0.509) for the second stage of labor. In our study delivery and the cause of cesarean delivery and Apgar score at 5 minutes’ infants were compared. in our study, the cesarean rate in the control group was higher, but the difference was not statistically significant (P =0.106).Conclusion: In total, according to the studies and research it seems that propranolol can be used to help labor.

Keywords:

propranolol , oxytocin , labor