Qurratul Ann Warsi - University of California and San Francisco, Department of Epidemiology and Biostatistics, ۱۸۲۵ ۴th street, Mission Bay, San Francisco, CA ۹۴۱۵۴, USA.
Meghana Kunduru - State University of New York Medical University, Syracuse, NY ۱۳۲۰۲, USA.
Manoochehr Karjoo - SUNY Upstate Medical University
Mirza Beg - ۴Associate Professor of Pediatrics, ivision of Pediatric Gastroenterology, Hepatology, and Nutrition, SUNY Upstate Medical University, ۷۵۰ East Adams Street, Syracuse, NY ۱۳۲۱۰, USA.

Crohn’s disease is an inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refractory genital swelling. We emphasize that Crohn’s disease must be considered in the differential diagnosis of recurrent, non-tender, erythematous and edematous lesions of the genital area. We conclude with future directions for diagnosing and managing vulvar Crohn’s disease in pediatric population.

Crohn’s disease (CD), Inflammatory Bowel Disease (IBD), Infliximab, Tumor necrosis factor alpha (TNF-α), Vulvar swelling