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Title

Nicotinic Acid Treatment for Retinal Vein Occlusion

Year: 1393
COI: JR_PSQ-2-1_002
Language: EnglishView: 209
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Authors

Abrishami M - Professor of Ophthalmology, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Science, Mashhad, Iran.
Mousavi Mn - Professor of Ophthalmology, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Science, Mashhad, Iran.
Zarei-Ghanavati S - Assistant Professor of Ophthalmology, Research Center for Patient Safety, Mashhad University of Medical Science, Mashhad, Iran.
Banaee T - Associate Professor of Ophthalmology, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Science, Mashhad, Iran.

Abstract:

Objectives: To evaluate the effect of nicotinic acid in management of retinal vein occlusions (CRVO or BRVO). Materials and Methods: This prospective nonrandomized pilot study included 20 patients (21 eyes) with CRVO or BRVO that received nicotinic acid (3 g/day) for 3 months. A complete ophthalmologic examination uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), testing for a relative afferent pupillary defect (RAPD), slit-lamp examination, gonioscopy, intraocular pressure (IOP) measurement, fundoscopy and fundus photography was performed. Results: Four patients did not appear for follow-up and hypersensitivity reaction to nicotinic acid and severe hyperglycemia happened in two patients. Therefore, the results of treatment in 16 eyes of 15 are reported. These patients had a mean age of 59.56 ± 11.12 years. The average length of follow-up was 8.6 ± 2.7 months. The mean BSCVA was 1.56 ± 0.66 before treatment, 1.38 ± 0.72 (p > 0.05) at one month and 0.88 ± 0.69 (p<0.01) at three months. The last BSCVA of all 16 eyes averaged 0.97 ± 0.73 (p<0.01). All patients had reduction of hemorrhagic events, cotton wool spots, edema in macula and disc, venous tortuosity, and dilation on basis of fundus photographs 3 months after treatment. Conclusion: Nicotinic acid usage provides enough time for development of collateral vessels, by induction of vasodilatation. Nicotinic acid use is tolerable and is related with mild systemic side effects.  

Keywords:

BRVO, CRVO, Niacin, Nicotinic acid, retinal vein occlusion

Paper COI Code

This Paper COI Code is JR_PSQ-2-1_002. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/942080/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
M, Abrishami and Mn, Mousavi and S, Zarei-Ghanavati and T, Banaee,1393,Nicotinic Acid Treatment for Retinal Vein Occlusion,https://civilica.com/doc/942080

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