Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-22-11_015

تاریخ نمایه سازی: 20 مهر 1398

Abstract:

Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.Materials and Methods: Tracheal smooth muscle were contracted by 10 μM methacholine or 60 mM KCl and the effects of cumulative concentrations of baicalein (5, 10, 20 and 40 mg/ml) and theophylline (0.2, 0.4, 0.6 and 0.8 mM) were evaluated. To examine the possible mechanism(s) of the relaxant effect of baicalein, its effect was also evaluated on incubated tissues with atropine, indomethacin, diltiazem, N(G)-Nitro-L-arginine methyl ester (L-NAME), glibenclamide, propranolol and chlorpheniramine.Results: A concentration-dependent and significant relaxant effect was seen for baicalein in non-incubated tissues contracted by KCl or methacholine (PConclusion: A potent relaxant effect comparable to the effect of theophylline was shown for baicalein, which was probably mediated via inhibition of histamine (H1) receptors, stimulation of beta2-adrenergic receptors and potassium channels activation.

Authors

Saeideh Saadat

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Javad Boskabadi

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Hossein Boskabady

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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