Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 22، Issue: 9
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-22-9_010
تاریخ نمایه سازی: 20 مهر 1398
Abstract:
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups. Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways. Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.
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Authors
Kambiz Gilany
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran|Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Ashraf Mohamadkhani
Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Saeed Chashmniam
Department of Chemistry, Sharif University of Technology, Tehran, Iran
Parisa Shahnazari
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
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