Mahdi Gholami - Oral and Maxillofacial Disease Research Center, Dental Faculty, Mashhad University of Medical Science, Mashhad, Iran.
Reza Shahakbari - Department of Oral and Maxillofacial Surgery, Dental Faculty, Mashhad University of Medical Science, Mashhad, Iran.
Somayeh Abdolahpour - Department of Oral and Maxillofacial Surgery, Dental Faculty, Mashhad University of Medical Science, Mashhad, Iran.
Masoud Hatami - Department of Oral and Maxillofacial Medicine, Dental Faculty, Mashhad University of Medical Science, Mashhad, Iran.

Introduction: Herpes zoster Infection (HZI) is a viral disease with painful skin rashes and blisters in a limited area on one side of the body, often in a strip. Osteonecrosis with spontaneous exfoliation of teeth in association with HZI of the mandibular nerve is a rare phenomenon. In this report, such an unusual complication of HZI is presented.   Case Report: The clinical course of a 53-year-old woman and a 54-year-old man with HZI associated with alveolar bone necrosis and tooth exfoliation were reviewed in order to develop a patient profile for this rare combination of physical findings.   Conclusion: In immunocompromised patients, the clinicians should consider HZI as a possible cause of tooth mobility, exfoliation, and alveolar osteonecrosis, which needs early intervention to prevent secondary complications.

Herpes zoster infection, Osteonecrosis, Tooth exfoliation