Effect of an Extended Lipid Core on Plaque Vulnerability: Assessment of Hemodynamic and Mechanical Parameters

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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ISME24_752

تاریخ نمایه سازی: 21 مهر 1398

Abstract:

The cardiovascular diseases such as atherosclerosis which is correlated with plaque rupture are the highest cause of death in the developed countries. In order to achieve a better understanding of the role of extension of the lipid core into the media on plaque vulnerability, we have studied the mechanical parameters of the arterial wall and plaque in addition to hemodynamics effects by utilizing a finite element method (FEM) and taking into account the fluid-structure interaction (FSI). Two numerical model groups, i.e. models without the lipid core extension (Group 1) and models with lipid core extended to the arterial wall (Group 2), were used in this study. The fully developed pulsatile velocity profile of the right coronary artery has been used as the inlet boundary condition and the pressure pulse has been applied as the outlet boundary condition. The non-Newtonian Carreau model has been used to simulate the non-Newtonian properties of blood. Our results show that, the wall shear stress in the stenosis throat experience more increase in group 1 in comparison with group 2. Comparing two groups, there is no significant difference in wall shear stress in the pre-stenosis region. The reversal flow region in the distal site of the stenosis was lengthened due to stenosis severity. However the length of recirculation zones decreased in the models of group 2 compared with the group 1. The tensile stresses increased within the fibrous cap structure at the proximal shoulder of the plaque. This maximum value increases with stenosis severity in the models of group 1. The tensile stresses are much higher in the models of group 2 than that of the models of group 1. In general, our results show that the extension of the lipid core into the media may increase plaque instability.

Authors

Morteza Teymoori

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan;

Mahmood Reza Sadeghi

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan

Mohsen Rabbani

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan