Investigation the effect of VDR Gene Polymorphisms (TaqI & FokI) in Risk of Postmenopausal Osteoporosis: A systematic review×

Background: Osteoporosis as a multifactorial age-related disease is a health concern characterized by increased risk of fragility fractures. In many studies it has been determined the association between genetic variants, and osteoporosis especially Vitamin D Receptor (VDR) as an important calcium metabolism pathway. The present study declares the relation between VDR polymorphisms, TaqI (rs731236) and FokI (rs2228570) in osteoporosis susceptibility of postmenopausal women. Methods: For this systematic review, the MEDLINE/Pubmed, Scopus, EMBASE, Magiran and Scientific Information Database (SID) were examined. The papers published between 2000 to May 2019 determine all the eligible studies about the association between Fok1 and TaqI polymorphisms of the VDR gene and osteoporosis risk in postmenopausal women. After applying the inclusion and exclusion criteria (non-original studies, etc.) to abstract, appropriate studies were selected and in order to find exact demographic and genetic information examined completely. Results: A total of 124 publications, 16 case–control studies were involved which gain our inclusion criteria. Overall, there are 1010 as cases (postmenopausal women with osteoporosis) and 725 controls (postmenopausal women without osteoporosis) for TaqI (8 publications) and 1655 cases and 1711 controls for FokI (9 publications, one in common with TaqI). The results were shown significant relation only in four of studies in TaqI (50%) and as same in FokI (44%) with osteoporosis in postmenopausal women. In the TaqI studies with meaningful relationship, Tt, tt and TT genotypes were protective, respectively. However, there was not enough evidence to indicate the superiority of any of the FokI genotypes. Conclusion: Our results show although many studies have not been able to find this association, but it can be considered possible that TaqI and FokI polymorphism might be associated with risk of osteoporosis in postmenopausal women.

Keywords:

Osteoporosis , Postmenopausal Women , Vitamin D Receptor , Systematic Review.