Co-administration of aspirin and conditioned medium improve functional recovery of optic chiasm in lysolecithin-induced demyelination model

derived-tissue iposead from medium conditioned and aspirin of application-co study, preset the In :Background in evaluated been has activation astrocytes and pathway optic of recovery functional on (CM-ADSC) cells stem into injected was uL),%\) LPC: Methods .chiasm optic of model demyelination induced-LPC)) lysolecithin i.p.)) intraperitoneal daily underwent Animals model. demyelination local the induce to mchias optic rat the The injection. LPC post days 12 for mg/kg ro of dose at aspirin of gavage oral and CM-ADSCs of injections injection LPC before VEPs)) recordings potential kedevo visual using assessed was signals visual of conductivity a receptor factor growth derived-platelet against Immunostaining lesion post 1 and V days on also and as (MOG) glycoprotein oligodendrocyte-myelin marker, OPCs)) cells precursor oligodendrocyte as a)PDGFR) brain on performed was marker astrocyte as GFAP)) protein acidic fibrillary glial and marker myelin mature aspirin and CM-ADSCs of application that showed results Our Results .injection LPC post 14 day at sections GFAP of number the addition In animals. receiving LPC in waves VEP of latency the reduced significantly positive OPCs of number The aspirin. and CM-ADSCs with treated animals in attenuated was cells expressing CM-ADSCs both of treatment under were which animals of chiasm optic in increased significantly also was cells and CM-ADSCs of administration-co that suggest study this of results the Overall, :Conclusion aspirin and model demyelination induced-LPC in activation astrocytes of level the attenuate aspirin

Keywords:

aspirin Aspirin medium , Conditioned cells , stem Mesenchymal chiasm , Optic ation , Demyelin Lysolecithin