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Paper
Title

Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review.

Year: 1398
COI: AMSMED20_310
Language: EnglishView: 214
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Natalia Vallianou - Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece
Catherine Tsang - Faculty of Health and Social Care, Edge Hill University, Ormskirk, Lancashire, United Kingdom
Mohsen Taghizadeh - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran
Amirhossein Davoodvandi - Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R., Iran

Abstract:

Background: The effect of cinnamon (Cinnamomum Zeylanicum) on serum C-reactive protein (CRP), an acute phase protein commonly used as a marker of inflammation, is uncertain. Therefore, the objective of the present study was to conduct a systematic review and meta-analysis of published randomized controlled trials (RCTs) of cinnamon to determine the effect on levels of serum CRP, relative to controls.Methods: Studies were identified by a search of electronic databases including PubMed, Cochrane Library, Google Scholar and Scopus before August 2018. Combined and stratified analyses were used. Weighted mean differences (WMD) and its 95% confidence interval were estimated for net change in serum CRP by using random-effects model. The heterogeneity of meta-analysis was assessed by χ2 and I2 test. Results: Six studies were identified, and data from 285 participants were included. Pooled analysis showed significant reductions in serum CRP (WMD: -0.81 mg/L, 95% CI: -1.36 to -0.26, p = 0.004), with significant heterogeneity between selected studies. Improvements in sub-group analysis were observed when baseline CRP levels were greater than 3 mg/dL, and in trials of > 12 weeks‟ duration. Doses <1500 mg/day and ≥1500 mg/day were effective in lowering serum CRP (WMD: -0.56 mg/dL, 95% CI: -1.01 to -0.10, p = 0.02 and WMD: -2.13 mg/dL, 95% CI: -4.08 to -0.19, p = 0.03), respectively, with significantly reduced heterogeneity in trials with lower doses of cinnamon <1500 mg/day (test for heterogeneity: P = 0.22 and I2 = 33%). No changes were found in controls. Conclusion: Cinnamon supplementation improves levels of serum CRP, particularly in chronic conditions, where basal CRP levels are raised. Further well-designed studies are warranted to confirm or not the above-mentioned findings.

Keywords:

Anti-inflammatory, CRP, Cinnamon, Meta-analysis, RCT

Paper COI Code

This Paper COI Code is AMSMED20_310. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/944645/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Vallianou, Natalia and Tsang, Catherine and Taghizadeh, Mohsen and Davoodvandi, Amirhossein,1398,Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review.,20th annual research congress of iranian medical sciences student,Kermanshah,https://civilica.com/doc/944645

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