Mohsen Foroughipour - Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Farzadfard - Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Meisam Aghaee - Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Ghabeli-Juibary - Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Peripheral nervous injury and neuromuscular complications from methamphetamine abuse has not been reported. The mechanism is not yet identified. Methods: Eight patients with lower extremity weakness following methamphetamine abuse were reported during December 2009 to May 2010. Results: Patients presented with lower extremity weakness. All patients were co-abusers of methamphetamine and opioids. Other clinical manifestations comprised of distal paresthesia of the lower extremities with progression to proximal portions, with minimal sensory involvement in the distal of the lower extremities. Electrodiagnostic findings were consistent with lumbosacral Radiculopathy. Vital signs were unremarkable and all laboratory tests were within normal limits. Follow-up examination after three months showed improvement of weakness in 3 patients. Conclusion: For patients with a history of illicit drug abuse and acute neuromuscular weakness, methamphetamine or heroin toxicity should be taken into account. Hence, urine morphine and amphetamine/ methamphetamine tests should be performed and serum lead and thallium levels should be evaluated. In addition, rhabdomyolysis and myoglobinuria should be worked up.  

Methamphetamine, Heroin, Radiculopathy, Neuropathy