Hassan Boskabadi - M.D., Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Moradi - Ph.D., Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Zakerihamidi - Ph.D., Department of Midwifery, Faculty of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran

Background: Biochemical markers including interleukins (ILs) has been proposed forearly diagnosis of asphyxia.Objective: This study has aimed to systematically review the significance of ILmeasurements in the diagnosis of perinatal asphyxia.Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, andScopus databases before 2017 were searched for the following keywords: asphyxia,neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers werefinally selected for evaluation. Interleukins under study were IL6 and interleukin. Interleukins had been measured in 10 studies by serum samples, 2 studies bysamples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood.The inclusion criteria were: studies on neonates, with adequate information from thetest results and studies using markers other than ILs to detect asphyxia; however,studies with only abstracts available were excluded.Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84.88%and the specificity of 85.43%, whereas IL-1B > 4.7 Pg/dl has the sensitivity of 78%and specificity of 83% in the diagnosis of neonatal asphyxia. Among diagnostic ILsfor neonatal asphyxia, combination of IL6 and IL-1B had the highest sensitivity, that is,92.9%.Conclusion: IL6 and IL-1B of serum samples were used in the early diagnosis ofperinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxiaand its intensity. In addition, simultaneous evaluation of IL-1B and IL6 can improve thesensitivity of the early diagnosis of perinatal asphyxia.

Diagnosis, Interleukins, Asphyxia neonatorum