Background: The importance of preclinical research in the field of stem cell and rehabilitation medicine is a known fact. This is mostly demonstrated in development of novel stem cell therapies as well as understanding more about the stem cell it-self. In more detail, during drug (in this case stem cells) devel-opment, preclinical testing is vital which includes monitoring, bio-distribution and pharmacological studies. We at TPCF are seeking to strive and work for bettering the preclinical studies in Iran.Materials and Methods: Cutting-edge technology and Imag-ing modalities are one of the most important tools for perform-ing informative and innovative preclinical studies. We also at TPCF are equipped with high technology imaging modalities, all of which are designed and manufactured by the TUMS knowledge-based companies. Moreover, TPCF is connected to the country s laboratory network so that researchers can use the lab s services at a lower cost.Currently, TPCF is composed of the following facilities: - Nuclear Medicine Services:• Micro-PET Imaging Laboratory• Micro-SPECT Imaging Laboratory• Handheld Gamma Camera Imaging Laboratory - Optical Imaging Services:• Optical Planar Imaging LaboratoryOptical Tomography Imaging Laboratory - Micro-CT Imaging Laboratory- Micro- Ultrasound Imaging Laboratory - Image Processing & Analysis Laboratory- Chemistry Laboratory - Radiochemistry Laboratory- Histology Laboratory - Molecular Biology Laboratory - Tissue Culture Laboratory - Small Animal Surgery Section - Small Animal Holding Results: Key features of TPCF: • There are roughly around 20 similar facilities in the whole world.• We are the only preclinical core facility in the entire Middle East.• In terms of the variety of imaging devices and lab services, TPCF is among the top 10 core facilities in the world.• All devices are made by Iran.• Builders are all professors of Tehran University of Medical Sciences.• Key services of TPCF:• In vivo Image acquisition services using the above imaging modalities • Image analysis services• Educating scientists, clinicians and pharma on the available cutting-edge technology through 3 level workshops, seminars and journal club• In vitro services: chemistry, biology, cell and tissue studies with focus on radioactive experiments• Animal care and surgery servicesConclusion: Stem cell and cell therapy are thought to be the fu-ture of Medicine. A straight forward but important question for any cell therapy is: Where do they go We at TPCF have estab-lished a facility where we could address this question and could lead us to identify how and why they go to a specific location. Gaining insight on these could then improve the efficacy of cell and stem cell therapies. For more information please visit us on www.TPCF.ir