Use of iPSC Derived Hepatocytes for Liver Genera-tion/Replacement
Publish place: 20th congress on reproductive biomedicine and 15th congress on stem cell biology & technology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
RROYAN20_022
تاریخ نمایه سازی: 29 مهر 1398
Abstract:
Terminal liver failure caused by acute liver toxicants or by cir-rhosis caused by alcohol, non-alcoholic steatohepatitis or viral infections, can only be treated with liver transplantation. How-ever, due to the short supply of organs, many patients cannot be transplanted. Therefore, other sources of cells are being evalu-ated, including hepatocytes from pluripotent stem cells (PSCs). Data will be presented demonstrating that hepatocytes (and endothelial cells) derived from PSCs can be contemplated for grafting in vivo in the setting of liver failure, or can be used to recreate liver tissue in vitro by recellularization of decellular-ized liver scaffolds.
Authors
t Tricot
KU Leuven Stem Cell Institute, Leuven, Belgium
m Kumar
KU Leuven Stem Cell Institute, Leuven, Belgium
b Topraksihar
KU Leuven Stem Cell Institute, Leuven, Belgium
j Deboeck
KU Leuven Stem Cell Institute, Leuven, Belgium