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The Effects of Microvesicles Released by Embryonic Carcinoma Stem Cells Treated with Retinoic Acid on Neu-ral Differentiation of Mesenchymal Stem Cells

تعداد صفحات: 1 | تعداد نمایش خلاصه: 79 | نظرات: 0
سال انتشار: 1398
کد COI Paper: RROYAN20_056
زبان Paper: Englishglish
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مشخصات نویسندگان Paper The Effects of Microvesicles Released by Embryonic Carcinoma Stem Cells Treated with Retinoic Acid on Neu-ral Differentiation of Mesenchymal Stem Cells

SH Danaeinezhad - Department of Molcular Genetics, Islamic Azad Tehran Medical Science University, Tehran, Iran
S Babashah - Department of Molecular Genetics, Faculty of Biological Scienc-es, Tarbiat Modares University, Tehran, Iran
H Fahimi - Department of Genetics, Faculty of Advanced Science and Tech-nology, Islamic Azad University Tehran Medical Branch, Tehran, Iran

چکیده Paper:

Background: Neurogenesis function is a limited process, so diseases associated with neurodegenerative diseases are a ma-jor problem. Replacing nerve cells instead of destroying cells to treat these diseases is a worthwhile solution. Therefore, the neural differentiation of mesenchymal stem cells can be a rea-sonable way to achieve this goal. EXOSOMES are nanovesi-cles of endocytic origin that have important role in extracellu-lar communication and potential usage for tissue regeneration. Exosomes have the potential to carry and deliver MicroRNAs. Materials and Methods: In this study, firstly embryonic car-cinoma cells with retinoic acid and cocktail differentiated into neuronal cells and their differentiation was confirmed by Con-trast phase microscopy images. The peripheral environment of embryonic carcinoma cells was collected for the isolation of exosomes and exosomal isolation was performed using dif-ferential centrifugation and ExoQuick, exosome precipitation solution protocol. Exosomes were identified by an electron microscope and confirmed by dynamic light scattering (DLS). Mesenchymal stem cells were treated with NT2-derived ex-osomes. Finally, mesenchymal stem cells changed morphology and then followed the process of apparent bipolar and multipole differentiation. Immunocytochemistry and real time PCR tech-niques were used to evaluate the expression of neuronal mark-ers.Results and Conclusion: This study was the first evidence of the finding that exosomal microvesicle cells, secreted from neu-ronal differentiation cells, can induce neural differentiation in mesenchymal stem cells.

کلیدواژه ها:

Microvesicles, Exosomes, Stem Cells, Embryonic Carcinoma Cells, Neural Differentiation

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/950191/

کد COI Paper: RROYAN20_056

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined,1398,The Effects of Microvesicles Released by Embryonic Carcinoma Stem Cells Treated with Retinoic Acid on Neu-ral Differentiation of Mesenchymal Stem Cells,بیستمین کنگره بین‌المللی بیولوژی تولید مثل و پانزدهمین کنگره بین‌المللی سلول های بنیادی,Tehran,,,https://civilica.com/doc/950191

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Danaeinezhad, SH؛ S Babashah و H Fahimi)
برای بار دوم به بعد: (1398, Danaeinezhad؛ Babashah و Fahimi)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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