A Farasatkia - Department of Materials Engineering, Isfahan University of Tech-nology, Isfahan, Iran
M Kharaziha - Department of Materials Engineering, Isfahan University of Tech-nology, Isfahan, Iran
F Ashrafizadeh - Department of Materials Engineering, Isfahan University of Tech-nology, Isfahan, Iran
S Salehi - Institute of Anatomy, Essen University Hospital, University of Duisburg-Essen, Germany

Background: Due to the increasing incidence of diseases and injuries to the cornea of the human eye and the limitation of this sensitive tissue to receive medical treatments or ocular im-plants, as well as corneal transplantation problems, cornea re-construction is desirable.Materials and Methods: Nanocomposite membrane of Gel-Ma-silk nano fibroin is prepared. The silk nanofiber reinforce-ment increases both transparency and strength of the hydrogels improving handling and integrity.The wettability, transparency and mechanical properties of the composites with different volume ratios of GelMa/SNF were measured.Conclusion: According to research on corneal stromal tissue engineering, the construction of bi-sticky scaffolds with suffi-cient transparency and the ability to accelerate tissue regenera-tion is prepared and characterized.

GelMA, Silk Nanofibrill, Nanocomposite, Stroma, Corneal Tissue Engineering