N Rajabi Dehnavi - Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
M Kharaziha - Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
R Emadi - Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
S Soltani - Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Background: Recently, different kinds of adhesive surgi-cal sealants have been used for healing or regenerating of the ruptured tissues. Between them, hydrogel-based bioadhesives have been widely applied as alternatives for sutureless wound closures. However, most of them reveal various disadvantages such as low adhesion, unsuitable mechanical strength and cyto-toxicity concerns.Materials and Methods: To overcome the challenges facing with previous sealants, a novel smart hydrogel with in-situ gelation property was prepared based on gelatin. Due to good biocompatibility, biodegradability, nonimmunogenicity and ac-cessibility gelatin based materials have been widely used in dif-ferent studies for surgical sealants. In this research, two types of modifications were applied on the structure of gelatin consisting of thiolation and methacryloyl process.Results: Results demonstrated that compared to methacrylated gelatin (GelMA), the mechanical strength of hybrid hydrogel consisting of thiolated gelatin and GelMA was significantly in-creased (upon 6 times). Moreover, the hybrid hydrogel revealed less than 10% energy loss in five-cycle compression test.Conclusion: It could be concluded that the combination of in-jectability, rapid mechanical recovery with at least energy loss and appropriate mechanical properties of hybrid hydrogel could make it appropriate as a sealant for internal surgeries.

Thiolated Gelatin, Gelma, Wound Healing Application