Study The Protective Effect of Kombucha on Reduc-ing The Adverse Effects of Silver Nanoparticles on The In-dexes Oxidative Stress (FRAP, MDA) and Serum Testoster-one Hormones NMRI Mice

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

RROYAN20_318

تاریخ نمایه سازی: 29 مهر 1398

Abstract:

Background: Today, nanotechnology is one of the most rele-vant topics in the world of science. Among nanoparticles, silver nanoparticles are widely used in modern technology, especially in medicine. Due to their small size, these particles pass through the cell membrans and blood testis barrier and even lead to oxi-dative stress in the male reproductive system. Kombucha is a traditional fermentation drink with a strong antioxidant proper-ties that evaluates the anti-oxidant activity of the Kombucha by performing DPPH and ABTS tests. The aim of this study was to investigate the protective effect of as a potent Kombucha an-tioxidant against the effects silver nanoparticle on blood serum testestron and the level of lipid peroxidation in mice.Materials and Methods: Adult NMRI mice were randomly divided into 4 groups (n=6), control, Silver nanoparticles (500 mg/kg/day), Kombucha extract (9 ml/kg/day) and Silver nano-particles + Kombucha extract, and treated for 35 days.Blood Samples Were teken form the heart.Serum Samples Were col-lected and biochemical evaluations used. Cambacha was pre-pared industrially, then the amount of polyphenols and DPPH and ABTS radicals and its carbohydrates, as well as glucuronic acid (by HPLC), were measured. The results were analyzed by one-way ANOVA and Tukeyʼs test and the means were consid-ered significantly different at P<0.05Results: There was a significant decrease in testosterone levels in the serum of treated rats with silver nanoparticles (p <0.05) and there was a significant increase in antioxidant capacity. Moreover, malondialdehyde level in this group was significant-ly higher than that in the control group. (P <0.05). The above parameters in the nanoparticle group + kambuca were largely compensated for the silver nanoparticle group.Conclusion: The Kombucha extract was able to protect against the seminal vesicle damage caused by silver nanoparticles by reducing the oxidative stress.

Authors

SA Miri

Department of Biology, Faculty of Science, Arak University, Arak,Iran

SMA Shariatzadeh

Department of Biology, Faculty of Science, Arak University, Arak,Iran