Effect of Melatonin on The Number and Quality of The Egg and The Number of Embryos in The Antagonist Intracytoplasmic Sperm Injection Cycle

Background: In women with a history of intracytoplasmic sperm injection (ICSI), this study was conducted to investigate the effect of melatonin on the number and quality of the egg and the number of embryos in the antagonist cycle. The primary focus of our present study was to evaluate the influence of Me-latonin on oocyte and embryos quality.Materials and Methods: A group of 100 female infertility cli-ents from Qom Infertility center Acecr were randomly selected and divided into two groups. Group 1 received melatonin 3mg and group 2 received matching placebo capsule. At the same time as the start of gonadotropin drugs, the group1 was given a melatonin capsule at night and continued until the oocyte re-trieval day.Results: According to the findings of the study, the average number of adult oocytes (MII) in group1 was more than group 2(88.5 vs. 56.4) and this difference was significant. Also, there was a significant difference between the mean number of im-mature oocytes (MI) in both groups .Conclusion: Despite the positive effect of melatonin on the number of MII oocytes and the improvement in the quality and number of mature oocytes, Melatonin has no significant effect on the number of embryos during antagonist cycle.

Keywords:

Melatonin , Oxidative Stress , Infertility