Optimal Method of Control Ovarian Stimulation in Patients with Polycystic Ovarian Syndrome; A Randomized Controlled Trial

Background: Currently, optimal method of ovarian stimulation in patients with polycystic ovarian syndrome is unknown. the present research aims to study the efficiency of minimal ovarian stimulation method in the treatment of infertile patients with polycystic ovarian syndrome and also the effect of gonadotro-pin type on treatment cycles with antagonist GnRH.Materials and Methods: A total of 120 eligible patients were randomly allocated into four groups of ovarian stimulation to IVF/ ICSI: minimal ovarian stimulation with recombinant FSH, minimal ovarian stimulation with Human menopausal gonad-otropin, mild ovarian stimulation with recombinant FSH and mild ovarian stimulation with Human menopausal gonadotro-pin. IVF/ICSI outcomes were compared between groups. Data analysis included t test, ANOVA and χ2.Results: Demographic characteristics and hormonal profiles of the patients did not differ between groups. The statistical analysis showed that there were significant differences between groups regarding the stimulation duration (P < 0.000), number of retrieved oocytes (P = 0.000), number of obtained embryos (P = 0.001) and also cancellation (P = 0.01) and OHSS risk (P= 0.008). There were no statistically significant differences in the fertilization rate (P= 0.815) and implantation rate (P= 0.654) between the groups.Conclusion: On the basis of present results the minimal ovari-an stimulation with human menopausal gonadotropin is optimal method of control ovarian stimulation in patients with polycys-tic ovarian syndrome; however, larger randomized clinical tri-als are required.

Keywords:

Polycystic Ovarian Syndrome , Minimal Ovarian Stimulation , Mild Ovarian Stimulation