Evaluation the Effect of Anti-thyroid Antibody on Intracytoplasmic Sperm Injection in Infertile Euthyroid Patients

Background: Thyroid gland disorders in adults are often caused by autoimmune processes that trigger excessive thyroid hormones or damage to the gland and reduce the production of thyroid hormones. Antithyroid proxidase antibody and anti-thyroglobin antibody, also called anti-microsomal antibody, are found in Hashimoto s thyroiditis, Graves disease, postpartum thyroiditis, and chronic pain-free thyroiditis. Contradictory reports on the effect of anti-thyroid antibodies in cycles IVF is there. Considering the controversial studies on the effect of anti-thyroid antibodies in IVF-ET candidates in order to in-vestigate the presence of this antibody in HIV patients in the Motahari Hospital, this study was designed to investigate the association and effect of ATA in IVF cycles.Materials and Methods: : In the procedure, patients with IVF-COH who were candidates for IVF-COH were screened for se-rum TSH and anti-TPO levels. Blood samples were taken at -70 ° C and AntiTPO was evaluated in all samples. TSH and T4 levels have been used to evaluate the thyroid gland activ-ity. Then, the patients were followed up and ICSI results were evaluated in two groups. After extraction of the dominant fol-licle, the injected HCG injection of 36-34 units of ascized and ICSI follicles was performed and finally, ICSI and the number of pregnancy and abortion were evaluated in both groups.Results: In this study, 119 female candidates for IVF-ET were evaluated. The mean ± standard deviation of the age of the women was 32.24 ± 5.63 years (the lowest and highest were 21 and 44 years, respectively). We divided the subjects into two groups as the first positive group in terms of TPO antibody and the second group negative TPO antibody. Of the 119 women examined, 100 patients (84%) were negative for TPO and 16 (16%) were positive for this antibody. The mean number of oo-cytes in the first group was 8.54 ± 5.7 and 8.54 ± 16.4 in the first group (P value = 51.5). . The mean number of embryos in women with positive TPO was higher than those with negative TPO (Pvalue = 0.21). The frequency of positive βHCG in the first group (31.6) and in the second group (19) was 19 (P value 0.22). The side effect of OHSS was in the first group (15.8) and in the second group (8) 8. (07/0 = P value). The frequency of abortion in the first group (40) 2 and in the second group (52.6) was 10. (1 = Pvalue)Conclusion: In this study We compared the prevalence of posi-tive anti-thyroid antibodies, the number of oocytes, the number of embryos derived from cycles, the frequency of positive IVF, and the side effects of βHCG, including excessive ovarian hy-perstimulation syndrome, frequency of abortion, and multiplic-ity of frequency in these two groups .Considering the fact that there is no significant difference between the existing cases, further studies are needed on the importance of the anti-thyroid antibody response in IVF cyclist candidates.

Keywords:

ICSI , Anti TPO , Infertility , IVF