The Assessment of Sufficient and Insufficient Vita-min D in Treatment of Infertile PCOS Patients

Background: Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS). 67–85% of women with PCOS having serum concentrations of 25-hydroxy vitamin D (25OHD) <20 ng/ml. Some evidence is suggested that vitamin D deficiency has a role in incidence of PCOS patients . The aim of this study is to assess the effect of sufficient and insufficient levels of vitamin D on treatment of PCOS infertile patients.Materials and Methods: In this clinical trial, 60 PCOS infer-tile patients referred to Dr.rasekh clinic that randomly divided in case and control groups. Each of these two groups were ran-domly divided into case and control groups (15 participants in each group). Data collection was performed via questionnaires by midwives and statistical analysis by SPSS 21.Results: There was a significant relationship between follicu-lar size and use of vitamin D (P<0.05). Increased endometrial thickness and reduced BMI was detected In using vitamin D groups. The overall pregnancy rate was twenty (66.7%) that was related to using vitamin D groups.Conclusion: Vitamin D has a positive effect on the treatment of PCOS patients. Although response to the treatment is better in patients with insufficient vitamin D levels, but prescription of this vitamin in patients with sufficient vitamin D level is also effective . According to rare side effects related to this vitamin, its low cost and toxicity ,we recommend to add 1000 units of vitamin D3 daily to drug regimen of infertile PCOS patients.

Keywords:

Vitamin D , PCOS , Infertility , Pregnancy Rate