PCOS Infertile Patients Treatment with Optimal Results and Decrease the Rate of OHSS

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women in the repro-ductive age group, and is one of the most common causes of ovarian hyperstimulation syndrome(OHSS) in infertile patients. The aim of this study was decreased OHSS due to induction of ovulation with clomiphene citrate and then letrozole in compar-ison of letrozole and cabergolin and an optimal pregnancy rate. Materials and Methods: This is prospective clinical research from Dr.Rasekh infertility clinic,jahrom city, Iran. 64 infertile PCOS women were selected with 47 months infertility. The av-erage age of them is 27.3 years (STD=5). The patients were divided into two groups: Group A; 36patients (40%); initially tablet clomiphene citrare (from day 3 of menstrual cycle),then the second drug Letrozole was started from day 8 to 11 men-strual cycle. Group B; 28 patients (31.1 %); initially tablet Letrozole (from day 3 of menstrual cycle),then the second drug cabergolin started from day 8 to 11 menstrual cycle. Pregnancy rate in group A, 8 (22%) and in group B; 6(21%). The patients were monitored for ovulation by transvaginal ultrasonographic folliculometry, with measurement of number and size of the fol-licles, as well as endometrial thickness. Human chorionic gon-adotrophin (HCG) was injected intramuscularly when at least one mature follicle 18-22 mm diameter .Data was analyzed with SPSS version 21.Results: The rate of OHSS was similar in both groups nearly zero (P<0.05). This means that both methods of treatment can be prevented the creation of OHSS. Pregnancy rate in both groups was almost the same (P<0.05).Conclusion: We recommend for the prevention of OHSS that is a serious complication of PCOS infertile women treatment which one of the two mentioned methods is to be used. Whilst in both methods has been favorite fertility rate. The goal of treatment is minimal side effects with optimal result.

Keywords:

OHSS , PCOS , Clomiphen , Letrozole , Cabergolin