Association Study of HSP90 Gene Expression and Total Antioxidant Capacity (TAC) with Sperm Motility in Infertile Patient

Background: Heart shock proteins are a group of proteins that play an important role in fertility ability and important many studies verified that balance disturbance between antioxidants and free radicals has a distractive effect on sperm competence that aim of this study was to evaluate the correlation between sperm motility, hsp90gen expression and total antioxidant value in infertile patterns.Materials and Methods: The study was performed on 50 in-fertile and 10 fertile individuals according to WHO criteria. Briefly after sample collection, sperm motility, total antioxidant values and gene expression were evaluated.Results: Progressive sperm mobility progressive sperm mo-tility rate decreased significantly in infertile group (24.33%, 17.25%) as compared to control group (42.22%, 31.55%). per-centage of inactive sperm rose dramatically in infertile group (56.87%) in comparison with fertile group (26.23%) significant decrease of TAC was observed in fertile patients there wasn’t any observable differences between two experimental group gene expression.Conclusion: It seems that sperm motility is associated with to-tal antioxidant, but independent from hsp90 gene expression.

Keywords:

HSP90 , Antioxidant , Sperm