Evaluation Effect of Curcumin in Treatment of Poly-cystic Ovary Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women ages reproduction, asso-ciated with a lot of cardiometabolic consequences, with obesity, insulin resistance, and hyperandrogenemia. Due to the compli-cations caused by the use of old therapies، today more and more new treatment has been taken into account such as curcumin. Curcumin is one of the principal anti-inflammatory and health-ful components of turmeric comprising 2-8% of most turmeric preparation.Materials and Methods: A literature search was conducted through PubMed and Science direct to identify the effect of curcumin on PCOS Results: According to studies, curcumin can cause a reduction in lipid profile such as Triglyceride، T-Chol، LDL-C and T-Chol/HDL-C ratio. A number of studies have shown curcumin was associated with a significant reduction in liver fat content and plasma level of aspartate aminotransferase (AST) and ala-nine aminotransferase (ALT) and glycated hemoglobin. Cur-cumin Can reduce in plasma level of glucose and increase the insulin level as a result Can improve insulin resistance in PCOS patient. Curcumin also effects on obesity which is an inflam-matory process. As a result, it reduces inflammatory cytokines such as TNFa، adipokines، adiponectin، IL18, and IL6.Conclusion: Since curcumin effects on inflammatory markers and insulin resistance we can with more studies use it as an adjunct to other drugs in the treatment of PCOS.

Keywords:

Polycystic Ovarian Syndrome , Curcumin , Inflamma-tory Factors , Insulin Resistance