Amir Hemmati - Students Research Committee, Ardebil University of Medical Sciences, Ardebil, Iran
Mohammad Mehrtak - Department of Public Health, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran

Background: About 50% of people around the world are infected with Helicobacter pylori. The annual incidence of helicobacter pylori infection is 3-16% and 0.6% in developing and developed countries respectively. The aim of this study was to review antibiotic resistance of this organism in all over the world.Method: A literature review articles using the databases such as Pubmed, ISI, Embase, Google scholar and Scopus between 2000-2018 years ,by keywords Helicobacter pylori and Antibiotic resistance which contains 63 articles had been collected. Finally 22 Iranian, 7 Asian, 4 African, 5 American and 25 European articles have been selected and reviewed Results: Iranian studies reported very high resistance against metronidazole (61.7%), which is roughly consistent with the results of other Asian countries (49.8%). The average resistance was lower in Iranian in comparison with African countries (96. 5%). The mean ciprofloxacin resistance was 20% in Iran; it was 13. 4% in France and 40.1% in Italy.Conclusion: The average antibiotic resistance is higher in Iran than developed countries . According to the available statistics various antibiotic resistance tests are necessary for better treatment strategy selection.

Helicobacter pylori, Antibiotic resistance, Iran