Cutis Aplasia Review of the Literature and A Case Report

Cutis aplasia is a heterogeneous group of disorders characterized by well circumscribed focal absence of epidermis, dermis and occasionally subcutis at birth . The majority of cases involves the vertex of the scalp overlying the sagittal sinus, in proximity to the hair whorl, and may be associated with other congenital anomalies. However, skin defects may also occur on other regions such as the face, trunk and limbs, sometimes symmetrically . The diameter of the scalp defect ranges between 0.5 and 10 cm . The lesions are non inflammatory and well demarcated, superficially eroded to deeply ulcerated and occasionally already healed with scarring alopecia at birth. Larger defects are often deeper and may extend to the dura or the meninges, complicating the clinical course of the disease . The lesions may be single or multiple. The etiology of this group of diseases is not completely understood and may be different in the subtypes. Viral infections, ischemic/thrombotic events, involution of an intrauterine hemangioma, amniotic adherence, autosomal dominant and recessive varians and teratogenic medications such as methimazole, misoprostol, carbimazole, valproic acid . This article presents a case of ACC in a newborn whose mother was treated with methimazole due to thyrotoxicosis during the first trimester of pregnancy.

Keywords:

Aplasia cutis , management