MSCT and HSCT in Multiple Sclerosis

The advances in technology of stem cells in the recent decades opened an opportunity window to consider different types of these cells as a kind of therapy for some chronic disabling neurological diseases. Stem cells have two major potentials for therapy; they can repair andreplace the damaged tissues and also they can modulate the inflammations. So these therapeutic potentials reserve them as a new promising options for treatment of inflammatory and neurodegenerative disorders. There are some safety results in application of Mesencheymalstem cells(MSCs) in Multiple Sclerosis(MS). some other limited open label trials emphasis to the efficacy of them. Also the results of MESEMS trial, the greatest international randomized clinical trial on application of MSCs in MS, in that we also involved, will be publishedsoon. MSCs in such these trials are autologous and they have been obtained from Bone marrow or Placenta. There is also some promising data of application of autologous hematopoietic stem cells(AHSC) in MS which seems to be promising specially in aggressive MS. In summary, in this review presentation we try to address, the different stem cell types, their mechanism of actions and the promising role of stem cell therapy in MS and as well as some new clinical trials in cell therapy in MS.