Structural Concepts to Target Autoimmune Encephalitis

Autoimmune encephalitis was is associated with autoantibodies targeting NMDA receptors and voltagegated potassium channels. Autoantibodies modulate target function which in turn modulates target trafficking.Therefore, autoantibodies effects may include direct functional modification (e.g. calcium influx via NMDA receptors or excitotoxicity by modulation of Kv channel function). An attractive approach to counteract autoantibody effects is to interfere with autoantibodyassociatedconformational changes in target proteins. Structural mechanisms and potential in vitro assays for evaluation of promising compounds will be presented